Quantitative assessment of tumor vasculature and response to therapy in kaposi's sarcoma using functional noninvasive imaging.
Hassan M, Little RF, Vogel A, Aleman K, Wyvill K, Yarchoan R, Gandjbakhche AH. Source Laboratory of Integrative and Medical Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. hassanm@mail.nih.gov
Abstract
Two noninvasive methods, thermography and laser Doppler imaging (LDI), were assessed for their ability to quantitatively assess parameters of vascularity in lesions of HIV-associated Kaposi's sarcoma (KS). Thermography and LDI images of a representative KS lesion were recorded in 16 patients and compared to normal skin either adjacent to the lesion or on the contralateral side. Eleven of the 16 patients had greater than 0.5 degrees C increased temperature and 12 of the 16 patients had increased flux (measured by LDI) as compared to normal skin. There was a strong correlation between these two parameters (R = 0.81, p < 0.001). In ten patients, measurements were obtained prior to therapy and after receiving a regimen of liposomal doxorubicin and interleukin-12. After 18 weeks of therapy, temperature and blood flow of the lesions were significantly reduced from the baseline (p = 0.004 and 0.002 respectively). These techniques hold promise to assess physiologic parameters in KS lesions and their changes with therapy.
PMID: 15453810 [PubMed - indexed for MEDLINE
Wednesday, September 30, 2015
Monday, September 21, 2015
Mammography (anatomical) and Thermography (physiological) A more effective screening combination for Early Detection?
Mammography (anatomical) and Thermography (physiological) A more effective screening combination for Early Detection?
• Information Source: www.breastthermography.com
EARLY DETECTION MEANS LIFE
Breast cancer is the most common cancer in women, and the risk increases with age (1).
Risk is also higher in women whose close relatives have had the disease. Women without
children, and those who have had their first child after age 30, also seem to be at higher
risk. However, every woman is at risk of developing breast cancer. Current research
indicates that 1 in every 8 women in the US will get breast cancer in their lifetime (1).
Studies show an increase in survival rate when breast thermography and
mammography are used together(3).
DII’s ability to detect thermal signs that may suggest a pre-cancerous state of the breast,
or signs of cancer at an extremely early stage, lies in its unique capability of monitoring the
temperature variations produced by the earliest changes in tissue physiology (function)
(3,6,7,8,9). However, DII does not have the ability to pinpoint the location of a tumor nor can it
detect 100% of all cancers. Consequently, Digital Infrared Imaging’s role is in addition (an
adjunct) to mammography and physical examination, not in lieu of. DII does not replace
mammography and mammography does not replace DII, the tests complement each other.
Since it has been determined that 1 in 8 women will get breast cancer, we must use every
means possible to detect cancers when there is the greatest chance for survival. Proper use
of breast self-exams, physician exams, DII, and mammography together provide the
earliest detection system available to date (3,7,8,9). If treated in the earliest stages, cure rates
greater than 95% are possible (3,6).
REFERENCES
1. American Cancer Society – Breast Cancer Guidelines and Statistics, 1999-2005
2. I. Nyirjesy, M.D. et al; Clinical Evaluation, Mammography and Thermography in the Diagnosis of Breast Carcinoma. Thermology, 1986; 1: 170-173.
3. M. Gautherie, Ph.D.; Thermobiological Assessment of Benign and Malignant Breast Diseases. Am. J. Obstet. Gynecol., 1983; V 147, No. 8: 861-869.
4. C. Gros, M.D., M. Gautherie, Ph.D.; Breast Thermography and Cancer Risk Prediction. Cancer, 1980; V 45, No. 1: 51-56.
5. P. Haehnel, M.D., M. Gautherie, Ph.D. et al; Long-Term Assessment of Breast Cancer Risk by Thermal Imaging. In: Biomedical Thermology, 1980; 279-301.
6. P. Gamigami, M.D.; Atlas of Mammography: New Early Signs in Breast Cancer. Blackwell Science, 1996.
7. J. Keyserlingk, M.D.; Time to Reassess the Value of Infrared Breast Imaging? Oncology News Int., 1997; V 6, No. 9.
8. P.Ahlgren, M.D., E. Yu, M.D., J. Keyserlingk, M.D.; Is it Time to Reassess the Value of Infrared Breast Imaging? Primary Care & Cancer (NCI), 1998; V 18, No. 2.
9. N. Belliveau, M.D., J. Keyserlingk, M.D. et al ; Infrared Imaging of the Breast: Initial Reappraisal Using High-Resolution Digital Technology in 100 Successive Cases of Stage I and II Breast Cancer. Breast Journal, 1998; V 4, No. 4
• Information Source: www.breastthermography.com
EARLY DETECTION MEANS LIFE
Breast cancer is the most common cancer in women, and the risk increases with age (1).
Risk is also higher in women whose close relatives have had the disease. Women without
children, and those who have had their first child after age 30, also seem to be at higher
risk. However, every woman is at risk of developing breast cancer. Current research
indicates that 1 in every 8 women in the US will get breast cancer in their lifetime (1).
Studies show an increase in survival rate when breast thermography and
mammography are used together(3).
DII’s ability to detect thermal signs that may suggest a pre-cancerous state of the breast,
or signs of cancer at an extremely early stage, lies in its unique capability of monitoring the
temperature variations produced by the earliest changes in tissue physiology (function)
(3,6,7,8,9). However, DII does not have the ability to pinpoint the location of a tumor nor can it
detect 100% of all cancers. Consequently, Digital Infrared Imaging’s role is in addition (an
adjunct) to mammography and physical examination, not in lieu of. DII does not replace
mammography and mammography does not replace DII, the tests complement each other.
Since it has been determined that 1 in 8 women will get breast cancer, we must use every
means possible to detect cancers when there is the greatest chance for survival. Proper use
of breast self-exams, physician exams, DII, and mammography together provide the
earliest detection system available to date (3,7,8,9). If treated in the earliest stages, cure rates
greater than 95% are possible (3,6).
REFERENCES
1. American Cancer Society – Breast Cancer Guidelines and Statistics, 1999-2005
2. I. Nyirjesy, M.D. et al; Clinical Evaluation, Mammography and Thermography in the Diagnosis of Breast Carcinoma. Thermology, 1986; 1: 170-173.
3. M. Gautherie, Ph.D.; Thermobiological Assessment of Benign and Malignant Breast Diseases. Am. J. Obstet. Gynecol., 1983; V 147, No. 8: 861-869.
4. C. Gros, M.D., M. Gautherie, Ph.D.; Breast Thermography and Cancer Risk Prediction. Cancer, 1980; V 45, No. 1: 51-56.
5. P. Haehnel, M.D., M. Gautherie, Ph.D. et al; Long-Term Assessment of Breast Cancer Risk by Thermal Imaging. In: Biomedical Thermology, 1980; 279-301.
6. P. Gamigami, M.D.; Atlas of Mammography: New Early Signs in Breast Cancer. Blackwell Science, 1996.
7. J. Keyserlingk, M.D.; Time to Reassess the Value of Infrared Breast Imaging? Oncology News Int., 1997; V 6, No. 9.
8. P.Ahlgren, M.D., E. Yu, M.D., J. Keyserlingk, M.D.; Is it Time to Reassess the Value of Infrared Breast Imaging? Primary Care & Cancer (NCI), 1998; V 18, No. 2.
9. N. Belliveau, M.D., J. Keyserlingk, M.D. et al ; Infrared Imaging of the Breast: Initial Reappraisal Using High-Resolution Digital Technology in 100 Successive Cases of Stage I and II Breast Cancer. Breast Journal, 1998; V 4, No. 4
Wednesday, September 9, 2015
Application of thermography in dentistry--visualization of temperature distribution on oral tissues.
Application
of thermography in dentistry--visualization of temperature distribution
on oral tissues.
Komoriyama
M, Nomoto R, Tanaka R, Hosoya N, Gomi K, Iino F, Yashima A, Takayama Y, Tsuruta
M,
Tokiwa H,
Kawasaki K, Arai T, Hosoi T, Hirashita A, Hirano S.; Department of Dental
Engineering,
Tsurumi
University School of Dental Medicine, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama
230-8501, Japan.
The purpose of this study
was to devise and propose appropriate conditions for the photographing of
thermal images in the oral
cavity and to evaluate which thermography techniques can be applied to
dentistry by evaluating the
differences in temperature among oral tissues. Thermal images of oral cavities
of 20 volunteers in normal
oral condition were taken according to the guidelines of the Japanese Society
of Thermography, with five
added items for oral observation. The use of a mirror made it possible to take
thermal images of the
posterior portion or palate. Teeth, free gingiva, attached gingiva and alveolar
mucosa were identified on
thermal images. There were differences in temperature between teeth, free
gingiva, attached gingiva
and alveolar mucosa. These were nearly in agreement with the anatomical
view. Thermography need
no longer be restricted to the anterior portion using a mirror, and can
now be applied to the dental region.
Tuesday, September 1, 2015
Intraoperative monitoring of skin temperature changes of hands before, during, and after endoscopic thoracic sympathectomy: using infrared thermography and thermometer for measurement.
Intraoperative monitoring of skin temperature changes of hands before, during, and after endoscopic thoracic sympathectomy: using infrared thermography and thermometer for measurement.
Chuang TY, Yen YS, Chiu JW, Chan RC, Chiang SC, Hsiao MP, Lee LS. Source Department of Physical Medicine and Rehabilitation, Veterans General Hospital-Taipei; National Yang-Ming University School of Medicine, Taiwan, R.O.C.
Abstract OBJECTIVE: To investigate the roles of the second and third thoracic spinal segments in the preganglionic sympathetic innervation of the hand, and to compare skin temperature changes between thenar and other parts of palm before, during, and after endoscopic thoracic sympathectomy.
DESIGN: Twelve patients, four women and eight men, with severe palmar hyperhydrosis underwent endoscopic thoracic sympathectomy. The T3 segment was identified and dissected first, followed by T2 segment extirpation. Skin temperature changes of the hand were assessed by thermograph and thermometer simultaneously before, during, and after sympathectomy. Sympathetic skin responses were undertaken 1 day preoperatively and followed up 6 months postoperatively.
SETTING: An electrophysiological laboratory and operating room in a national medical center.
SUBJECTS: Twelve patients who sustained a profound degree of palmar hyperhydrosis.
INTERVENTIONS: Skin temperature differences of the hands were measured by infrared thermograph and thermometer before, during, and after endoscopic thoracic sympathectomy.
MAIN OUTCOME MEASURES: Group's average temperature differences, and sympathetic skin response (all or none response).
RESULTS: The T2 spinal segment is thought to be the main source of sympathetic outflow to the sweat glands of the hand. The group's average temperature changes were significantly higher at the 2nd through 5th fingers' tips than at the thenar after completion of T2 extirpation (p < .005).
CONCLUSIONS: Intraoperative monitoring of palmar skin temperature, as judiciously measured by infrared thermograph, yields useful information about the locations of the sympathetic segments and confirmation of their entire ablation by endoscopic thoracic sympathectomy.
Chuang TY, Yen YS, Chiu JW, Chan RC, Chiang SC, Hsiao MP, Lee LS. Source Department of Physical Medicine and Rehabilitation, Veterans General Hospital-Taipei; National Yang-Ming University School of Medicine, Taiwan, R.O.C.
Abstract OBJECTIVE: To investigate the roles of the second and third thoracic spinal segments in the preganglionic sympathetic innervation of the hand, and to compare skin temperature changes between thenar and other parts of palm before, during, and after endoscopic thoracic sympathectomy.
DESIGN: Twelve patients, four women and eight men, with severe palmar hyperhydrosis underwent endoscopic thoracic sympathectomy. The T3 segment was identified and dissected first, followed by T2 segment extirpation. Skin temperature changes of the hand were assessed by thermograph and thermometer simultaneously before, during, and after sympathectomy. Sympathetic skin responses were undertaken 1 day preoperatively and followed up 6 months postoperatively.
SETTING: An electrophysiological laboratory and operating room in a national medical center.
SUBJECTS: Twelve patients who sustained a profound degree of palmar hyperhydrosis.
INTERVENTIONS: Skin temperature differences of the hands were measured by infrared thermograph and thermometer before, during, and after endoscopic thoracic sympathectomy.
MAIN OUTCOME MEASURES: Group's average temperature differences, and sympathetic skin response (all or none response).
RESULTS: The T2 spinal segment is thought to be the main source of sympathetic outflow to the sweat glands of the hand. The group's average temperature changes were significantly higher at the 2nd through 5th fingers' tips than at the thenar after completion of T2 extirpation (p < .005).
CONCLUSIONS: Intraoperative monitoring of palmar skin temperature, as judiciously measured by infrared thermograph, yields useful information about the locations of the sympathetic segments and confirmation of their entire ablation by endoscopic thoracic sympathectomy.
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